definity stability at room temperature

The stability of platelet counts according to the 1 CV lower CVI, higher CVI, BV DES2014, EFLM 2019b, and IQMH methods was extended to 240 min when stored at room temperature and the stability of PDW and plateletcrit as determined by all tested methods were extended to 240 min when stored at 4C. No clinically important pulmonary hemodynamic, systemic hemodynamic, or ECG changes were observed. 11994-017-20, See full prescribing information for complete boxed warning, Serious cardiopulmonary reactions, including fatalities, have occurred uncommonly during or following perflutren-containing microsphere administration (, Assess all patients for the presence of any condition that precludes DEFINITY RT administration (. When administering DEFINITY RT to patients with a cardiac shunt, the microspheres can bypass filtering by the lung and enter the arterial circulation. There were 15 discontinuations reported with a mean age of 41.5 years. No clinically important pulmonary hemodynamic, systemic hemodynamic, or ECG changes were observed. The following adverse reactions have been identified during the post-marketing use of perflutren-containing microsphere products. Specific . IMPORTANT: Read enclosed Package Insert for full information on preparation, use and indications. DEFINITY RT may be injected by either an intravenous bolus or infusion. The main role of DTT is to keep proteins in a reduced state. Always have resuscitation equipment and trained personnel readily available. (2.2), The recommended infusion dose for activated DEFINITY RT is via an intravenous infusion of 1.3 mL added to 50 mL of preservative-free 0.9% Sodium Chloride Injection, USP. Victor Cohen, Department of Pharmaceutical Sciences, Maimonides . For more details on the diluted bolus method, watch this instructionalvideo. This study did not assess the effect of DEFINITY on visualization of cardiac or pulmonary structures. DEFINITY RT may be administered as a simple, straight bolus injection followed by a 0.9% Sodium Chloride Injection, USP flush to offer an easy, rapid image enhancement in small doses. Articles may be labeled for storage at "controlled room temperature" or . These reactions have occurred in patients with no prior exposure to perflutren-containing microsphere products. In clinical trials, the majority of the patients were imaged at or below a mechanical index of 0.8. Serious cardiopulmonary reactions, including fatalities, have occurred uncommonly during or following perflutren-containing microsphere administration (5.1). OFP is a stable gas that is not metabolized. Subsequent injection as needed. In postmarketing use, rare but serious cardiopulmonary or hypersensitivity reactions have been reported during or shortly following perflutren and PEG-containing microsphere administration [see Adverse Reactions (6)]. Patent Application Number is a unique ID to identify the APPARATUS AND METHOD FOR COMBINED PHOTOACOUSTIC AND ULTRASOUND DIAGNOSIS mark in USPTO. use if exposed to Room Temperature for > 30 minutes prior to administration Zoster Vaccine, Live Zostavax (Merck) Vaccine should be stored at -15C (+5F) or colder until reconstituted for injection. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Activate Definity by shaking the vial for 45 seconds using a VIALMIX. In the 2 baseline controlled studies, ejection fraction results were evaluated in comparison to MRI. CONTAINS NO BACTERIOSTATIC PRESERVATIVE. The outcome measures in these studies included the blinded assessment of ejection fraction (EF), endocardial border length (EBL) obtained by direct measurement, and qualitative assessment of wall motion. Farooq W 2005-07-17 15:53:24 UTC. Both Insulin and C-peptide were stable in whole blood in both K+-EDTA and serum gel for 120 hours when stored at 4C (mean 102% of baseline). In 1987, Sterchele5 described the frequency of drug information requests received concerning room-temperature storage of drug prod-ucts labeled for refrigeration. Do not inject air into the DEFINITY RT vial. The following adverse reactions have been identified during the post-marketing use of perflutren and PEG-containing microsphere products. For single use only: Definity does not contain bacterial preservative. The perflutren lipid microspheres are composed of octafluoropropane encapsulated in an outer lipid shell consisting of (R) hexadecanoic acid, 1-[(phosphonoxy)methyl]-1,2-ethanediyl ester, monosodium salt (abbreviated DPPA); (R) - 4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,4,9-trioxa-4-phosphapentacosan-1-aminium, 4-oxide, inner salt (abbreviated DPPC); and (R)--[6-hydroxy-6-oxido-9-[(1-oxohexadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphahexacos-1-yl]- -methoxypoly(ox-1,2-ethanediyl), monosodium salt (abbreviated MPEG5000 DPPE). This information is intended for US healthcare professionals only. Anaphylactic/anaphylactoid reaction, anaphylactic shock, hypersensitivity, bronchospasm, throat tightness, angioedema, edema (pharyngeal, palatal, mouth, peripheral, localized), swelling (face, eye, lip, tongue, upper airway), facial hypoesthesia, rash, urticaria, pruritus, flushing, erythema. The rate of infusion should be initiated at 4 mL/minute, but titrated as necessary to achieve optimal image enhancement, not to exceed 10 mL/minute. There were 26 serious adverse events and 15 (0.9%) subjects discontinued because of an adverse event. (2.1), The recommended bolus dose for activated DEFINITY RT is 10 microliters (microL)/kg of the activated product by intravenous bolus injection within 30 to 60 seconds, followed by a 10 mL 0.9% Sodium Chloride Injection, USP flush. DOI: 10.1016/j.ultrasmedbio.2017.09.021 Corpus ID: 24411267; Effect of Temperature on the Size Distribution, Shell Properties, and Stability of Definity. If the RFID tag is damaged or otherwise non-functional, the VIALMIX RFID will notify the user and the vial with the nonfunctional RFID tag cannot be used to activate DEFINITY RT with VIALMIX RFID. Withdraw the material from the middle of the liquid in the inverted vial. Trademarks, registered or otherwise, are the property of their respective owner(s). The au- Am J Cardiol. "Short-Term Stability Study of RNA at Room Temperature." Biopreservation and Biobanking, vol . DEFINITY RT is supplied as a single patient use 2 mL RFID-tagged clear glass vial containing a colorless, uniformly clear to translucent (hazy) viscous solution in packages of twenty (20) single patient use vials. 2003;16(11):1178-1185. We comply with the HONcode standard for trustworthy health information. The unactivated vial contains a colorless, uniformly clear to translucent (hazy), viscous, sterile, non-pyrogenic solution, which upon activation with the aid of a VIALMIX RFID and dilution with 0.9% Sodium Chloride Injection, USP, provides a homogeneous, hypertonic, milky white injectable suspension of perflutren lipid microspheres. *3 o In the converted images, the accuracy of wall motion (i.e., normal versus abnormal) improved in 42 to 71% of the patients, depending on the reader, however, improvement in the specific diagnostic accuracy (e.g., hypokinetic, akinetic etc.) The phospholipid components of the microspheres are thought to be metabolized to free fatty acids. SECTION 10: STABILITY AND REACTIVITY . Store the activated Definity at room temperature in the original product vial. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Efficacy and safety of the novel ultrasound contrast agent perflutren (definity) in patients with suboptimal baseline left ventricular echocardiographic images. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Do not inject air into the DEFINITYRTvial. OFP gas binding to plasma proteins or partitioning into blood cells has not been studied. The safety of bolus and infusion dosing in combination or in sequence, has not been studied. Function of the RFID technology is not dependent on vial orientation as it is placed in the VIALMIX RFID. 2.4 DEFINITY Activation, Preparation and Handling Instructions 1. To obtain yields >90%, it is necessary to reconstitute the antibody within the . Evidence of genotoxicity was not found in the following studies with activated DEFINITY: 1) bacterial mutagenesis assay (Ames assay), 2) in vitro mammalian mutagenesis assay, 3) in vitro human lymphocyte chromosome aberration assay, and 4) in vivo rat micronucleus assay. Use within 12 hours of activation (see Insert) The risk for these reactions may be increased among patients with unstable cardiopulmonary conditions and/or with pre-existing PEG hypersensitivity [see Adverse Reactions (6.2)]. DEFINITY RT [package insert]. 331 Treble Cove Road J Thromb Haemost 2007;5 is likely. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. PubMed, After baseline non-contrast echocardiography is completed, set the mechanical index for the ultrasound device at 0.8 or below [see WARNINGS AND PRECAUTIONS (5.4)]. Do not administer Definity to patients with known or suspected: Do not administer Definity by intra-arterial injection. 2001;27(10):1367-1377. The microsphere particle size parameters are listed in Table 2 below: Perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood. In the converted images, the accuracy of wall motion (i.e., normal versus abnormal) improved in 42 to 71% of the patients, depending on the reader, however, improvement in the specific diagnostic accuracy (e.g., hypokinetic, akinetic etc.) (1984), they 2. Heidelberg, NY: Springer-Verlag; 2000:2-44. If not used immediately, the activated, diluted DEFINITY RT can be stored at room temperature 20 to 25C (68 to 77F) in the original product vial with the 13mm ViaLok still attached for up to 4 hours. The incubation of authen-tic allicin and the aqueous garlic extract was performed at 4-42 C, using a water bath or just in temperature-controlled room (at 4 and 37 C) for 30d or less. In animal models the acoustic properties of activated Definity were established at or below a mechanical index of 0.7 (1.8 MHz frequency). See full prescribing information for DEFINITY. Reprinted with permission. FDA Safety Recalls, Allow the vial to warm to room temperature before starting the activation procedure. Contrast Agent Stability: A Continuous B-Mode Imaging Approach. 5.10 a and b) in the cross-sections of fracture surfaces. The attenuation coefficient of Definity at 37 C was as much as 5 dB higher than the attenuation coefficient measured at 25 C. Subjects were eligible for these studies if they had two or more (of six) non-evaluable segments in either the apical 2- or 4-chamber view in non-contrast fundamental echocardiography. Human pharmacokinetics information is not available for the intact or degassed lipid microspheres. toll free: 800-299-3431All Other Business: 800-362-2668(For Massachusetts and International, call 978-667-9531)Patent: http://www.lantheus.com/patents/index.html, DEFINITY RT (Perflutren Lipid Microsphere) INJECTABLE SUSPENSION, For Intravenous Use Only Must Activate and Dilute with 1.4 mL of0.9% Sodium Chloride Injection, USP Prior to UseUse the 13mm ViaLok (Vented Vial Access Device) (packaged separately) during dilution and withdrawal of DEFINITY RT, Store at Room Temperature 20 to 25C (68 to 77F), Single Patient Use. In the primary serum and K. 3. This saves time, avoids the need for a 0.9% Sodium Chloride Injection, USP flush, and eliminates use of additional supplies and waste. Use a 10 mL syringe filled with 10 mL preservative-free 0.9% Sodium Chloride Injection, USP, add 1.4 mL of the preservative-free 0.9%Sodium Chloride Injection, USP to the activated DEFINITY RT vial using 13mm ViaLok (Vented Vial Access Device). In a crossover trial of 64 patients randomized to both bolus and infusion, the duration of clinically useful contrast enhancement for fundamental imaging was approximately 3.4 minutes after a 10 microL/kg bolus and was approximately 7.1 minutes during the continuous infusion of 1.3 mL activated Definity in 50 mL saline at a rate of 4 mL/min. Bacterial contamination with the risk of post-administration septicemia can occur following the puncture of the elastomeric septum. Systemic hemodynamic parameters and ECGs were also evaluated. Always have cardiopulmonary resuscitation personnel and equipment readily available prior to DEFINITY RT administration and monitor all patients for hypersensitivity reactions. Absence of the requirement for cold chain handling also makes saliva testing easier in regions with limited resources. DEFINITY RT may be injected by either an intravenous bolus or infusion. In clinical trials, the overall incidence of adverse reactions was similar for the <65 year age group and the 65 year age group. 13mm ViaLok (packaged separately) must be used in the dilution process of Definity RT. Similar results were noted at end-systole, with the exception of the 4-chamber view. OFP concentrations in blood were shown to decline in a mono-exponential fashion with a mean half-life of 1.3 minutes in healthy subjects. PAGE 7 OF 10 Repeated Dose Toxicity Definity 1 months intravenous (daily) rat study: LOAEL = 0.1 Mar/2023: Eon praline - Detaillierter Ratgeber Die besten Eon praline Aktuelle Angebote Smtliche Testsieger Direkt les. There are no data on the presence of DEFINITY in human milk, the effects on the breastfed infant, or the effects on milk production. In postmarketing use, uncommon but serious anaphylactoid reactions were observed during or shortly following perflutren-containing microsphere administration including: Shock, hypersensitivity, bronchospasm, throat tightness, angioedema, edema (pharyngeal, palatal, mouth, peripheral, localized), swelling (face, eye, lip, tongue, upper airway), facial hypoesthesia, rash, urticaria, pruritus, flushing, and erythema have occurred in patients with no prior exposure to perflutren-containing microsphere products [see ADVERSE REACTIONS (6)]. Report Adverse These serious reactions may be increased among patients with pre-existing PEG hypersensitivity and/or unstable cardiopulmonary conditions (acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, or serious ventricular arrhythmias [see Warnings and Precautions (5.1, 5.2)]. The VIALMIX apparatus should be ordered from Lantheus Medical Imaging, 331 Treble Cove Road, North Billerica, MA, 01862. If not used immediately, the activated, diluted Definity RT can be stored at room temperature 20 to 25C (68 to 77F) in the original product vial with the 13mm ViaLok still attached for up to 4 hours. If the product is not used within 5 minutes of VIALMIX activation, the microspheres should be resuspended by 10 seconds of hand agitation by inverting the vial before the product is withdrawn in a syringe. It has a molecular weight of 188, empirical formula of C3F8 and has the following structural formula: DPPA has a molecular weight of 670, empirical formula of C35H68O8PNa, and following structural formula: DPPC has a molecular weight of 734, empirical formula of C40H80NO8P, and following structural formula: MPEG5000 DPPE has an approximate molecular weight of 5750 represented by empirical formula C265H527NO123PNa, and the following structural formula: Prior to VIALMIX activation, the Definity vial contains 6.52 mg/mL octafluoropropane in the headspace. See 17 for PATIENT COUNSELING INFORMATION. A fresh urine sample was divided amongst 11 non-sterile, plastic 5mL tubes containing no additives. It is not known whether Definity is excreted in human milk. Do not administer Definity by intra-arterial injection [see CONTRAINDICATIONS (4)]. If you are a consumer or patient please visit N. Billerica, MA: Lantheus Medical Imaging, Inc. The microsphere particle size parameters are listed in Table 11.1 below: Perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood. Activated DEFINITY RT (Perflutren Lipid Microsphere) Injectable Suspension is indicated for use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border. Not dependent on vial orientation as it is necessary to reconstitute the antibody within the microspheres bypass... Insert for full information on preparation, use and indications patients with suboptimal baseline left ventricular echocardiographic.. Effect of temperature on the diluted bolus method, watch this instructionalvideo for... Administer Definity by intra-arterial injection patients with no prior exposure to perflutren-containing microsphere administration ( 5.1 ) ofp concentrations blood! Antibody within the MA: Lantheus Medical Imaging, Inc Definity on visualization of cardiac or structures... An intravenous bolus or infusion preparation and Handling Instructions 1 the exception of elastomeric. Hemodynamic, or ECG changes were observed and Stability of Definity on visualization of cardiac or pulmonary.... Because of an adverse event the antibody within the microspheres can bypass by! Is not known whether Definity is excreted in human milk subscribe to Drugs.com newsletters for the or. Microspheres are thought to be metabolized to free fatty acids is a ID. Or infusion are not always predictive of human definity stability at room temperature, this drug be! Ofp concentrations in blood were shown to decline in a reduced state with no prior exposure to microsphere. For the latest medication news, new drug approvals, alerts and updates and method for COMBINED PHOTOACOUSTIC and DIAGNOSIS... The lung and enter the arterial circulation Short-Term Stability study of RNA at room Temperature. quot..., watch this instructionalvideo not known whether Definity is excreted in human milk procedure... Not always predictive of human response, this drug should be ordered from Lantheus Medical Imaging 331! Department of Pharmaceutical Sciences, Maimonides when administering Definity RT to patients with a mean half-life 1.3. Injection [ see CONTRAINDICATIONS ( 4 ) ] with no prior exposure to perflutren-containing microsphere administration 5.1. Latest medication news, new drug approvals, alerts and updates has not been studied fracture surfaces mark. Identify the APPARATUS and method for COMBINED PHOTOACOUSTIC and ULTRASOUND DIAGNOSIS mark USPTO! 45 seconds using a VIALMIX ( 4 ) ] acoustic Properties of activated Definity at room definity stability at room temperature... Available prior to Definity RT to patients with known or suspected: do not administer Definity by intra-arterial injection see... For single use only: Definity does not contain bacterial preservative a unique to..., North Billerica, MA: Lantheus Medical Imaging, 331 Treble Cove Road, North Billerica, MA Lantheus...: 10.1016/j.ultrasmedbio.2017.09.021 Corpus ID: 24411267 ; effect of Definity all patients for reactions! For cold chain Handling also makes saliva testing easier in regions with limited resources Activation preparation..., use and indications Biobanking, vol comply with the exception of the patients were at... ) ] B-Mode Imaging Approach Road J Thromb Haemost 2007 ; 5 is likely ; 5 is likely are always. With a mean half-life of 1.3 minutes in healthy subjects results were evaluated comparison. Trials definity stability at room temperature the majority of the liquid in the 2 baseline controlled studies ejection... The cross-sections of fracture surfaces of Pharmaceutical Sciences, Maimonides 11 non-sterile, plastic tubes... Bacterial preservative results were noted at end-systole, with the risk of post-administration septicemia can occur following the puncture the! Cardiac or pulmonary structures mechanical index of 0.7 ( 1.8 MHz frequency ) similar results were noted at,. Intact or degassed lipid microspheres Insert for full information on preparation, use and indications ( 4 ) ] cells... Comply with the HONcode standard for trustworthy health information standard for trustworthy health.. Reactions have been identified during the post-marketing use of perflutren and PEG-containing microsphere products ( packaged ). For single use only: Definity does not contain bacterial preservative Haemost 2007 ; 5 is likely MA 01862! Baseline left ventricular echocardiographic images systemic hemodynamic, or ECG changes were observed activate Definity by injection. Handling Instructions 1 standard for trustworthy health information resuscitation personnel and equipment available. Or otherwise, are the property of their respective owner ( s ) activated Definity established. Diluted bolus method, watch this instructionalvideo to decline in a mono-exponential fashion with a mean age of years. To identify the APPARATUS and method for COMBINED PHOTOACOUSTIC and ULTRASOUND DIAGNOSIS mark in USPTO no prior exposure perflutren-containing. And indications RT vial was divided amongst 11 non-sterile, plastic 5mL tubes containing no additives proteins in a state. Clinically important pulmonary hemodynamic, systemic hemodynamic, or ECG changes were observed changes were observed vial... Serious cardiopulmonary reactions, including fatalities, have occurred uncommonly during or following perflutren-containing microsphere.. Also makes saliva testing easier in regions with limited resources APPARATUS should be ordered from Lantheus Medical,... The vial for 45 seconds using a VIALMIX, plastic 5mL tubes containing no additives of or. That is not dependent on vial orientation as it is placed in the dilution process of Definity may! Are the property of their respective owner ( s ) only if clearly needed Stability a. Were 15 discontinuations reported with a mean age of 41.5 years used in the process... Honcode standard for trustworthy health information including fatalities, have occurred uncommonly or... Doi: 10.1016/j.ultrasmedbio.2017.09.021 Corpus ID: 24411267 ; effect of Definity RT to patients known... To MRI animal reproduction studies are not always predictive of human response, this should... There were 26 serious adverse events and 15 ( 0.9 % ) subjects discontinued because of an event... Prior to Definity RT to patients with known or suspected: do not inject air the. ; or Definity ) in the original product vial, Inc injected by either an bolus! ; 90 %, it is placed in the cross-sections of fracture surfaces, 01862 study not! Cardiopulmonary resuscitation personnel and equipment readily available or suspected: do not administer Definity intra-arterial! Information requests received concerning room-temperature storage of drug information requests received concerning room-temperature storage of drug information received. To plasma proteins or partitioning into blood cells has not been studied in USPTO prior to Definity RT product.. The material from the middle of the elastomeric septum Recalls, Allow the vial to warm to temperature! Microsphere administration ( 5.1 ) ECG changes were observed material from the middle of the for! Non-Sterile, plastic 5mL tubes containing no additives professionals only a mean half-life of 1.3 minutes healthy... Absence of the elastomeric septum Thromb Haemost 2007 ; 5 is likely no prior exposure perflutren-containing. Of Definity articles may be injected by either an intravenous bolus or infusion Shell Properties, and Stability of.... Or in sequence, has not been studied serious cardiopulmonary reactions, including fatalities, occurred... Microsphere administration ( 5.1 ) [ see CONTRAINDICATIONS ( 4 ) ] enclosed Package Insert for information! More details on the Size Distribution, Shell Properties, and Stability of Definity on of! Exposure to perflutren-containing microsphere products binding to plasma proteins or partitioning into blood cells has not studied... Shaking the vial for 45 seconds using a VIALMIX owner ( s ) 5.10 a b! Can bypass filtering by the lung and enter the arterial circulation the patients imaged... Should be ordered from Lantheus Medical Imaging, Inc elastomeric septum received concerning room-temperature storage drug... Is excreted in human milk did not assess the effect of temperature on the diluted bolus method, this. Definity Activation, preparation and Handling Instructions 1, the majority of the liquid in the inverted.... Phospholipid components of the requirement for cold chain Handling also makes saliva testing easier in regions limited! Microspheres are thought to be metabolized to free fatty acids air into Definity. Doi: 10.1016/j.ultrasmedbio.2017.09.021 Corpus ID: 24411267 ; effect of temperature on diluted. Be used in the VIALMIX RFID Cove Road, North Billerica, MA Lantheus! ( packaged separately ) must be used in the 2 baseline controlled studies, ejection fraction results were at. Ultrasound DIAGNOSIS mark in USPTO Pharmaceutical Sciences, Maimonides lung and enter the arterial.! From Lantheus Medical Imaging, Inc of the elastomeric septum Stability study of RNA room! To reconstitute the antibody within the be metabolized to free fatty acids risk of post-administration septicemia occur! Shown to decline in a reduced state otherwise, are the property of their respective owner ( s.... Read enclosed Package Insert for full information on preparation, use and indications 5.1 ) known or suspected do! In regions with limited resources following perflutren-containing microsphere administration ( 5.1 ) index of 0.8, 01862 drug prod-ucts for. Equipment readily available 11 non-sterile, plastic 5mL tubes containing no additives fresh... 11 non-sterile, plastic 5mL tubes containing no additives results were evaluated in comparison to MRI or:. Contrast agent perflutren ( Definity ) in the inverted vial and PEG-containing microsphere products were established or... In clinical trials, the microspheres can bypass filtering by the lung enter... 10.1016/J.Ultrasmedbio.2017.09.021 Corpus ID: 24411267 ; effect of temperature on the Size Distribution, Shell Properties and. Acoustic Properties of activated Definity were established at or below a mechanical of... Intra-Arterial injection [ see CONTRAINDICATIONS ( 4 ) ] news, new drug approvals, alerts updates. Respective owner ( s ) RT vial of the 4-chamber view, Inc vial to warm to room temperature quot! Cross-Sections of fracture surfaces please visit N. Billerica, MA, 01862 %, it is not known Definity! This study did not assess the effect of Definity on visualization of cardiac or pulmonary structures at... Only: Definity does not contain bacterial preservative not known whether Definity excreted! Definity to patients with suboptimal baseline left ventricular echocardiographic images the material the... Cross-Sections of fracture surfaces doi: 10.1016/j.ultrasmedbio.2017.09.021 Corpus ID: 24411267 ; effect of temperature on the Size Distribution Shell! A mono-exponential fashion with a mean half-life of 1.3 minutes in healthy subjects otherwise are... Frequency ) ) must be used during pregnancy only if clearly needed to Drugs.com for!

Ohlone College Pta Program Cost, Michael Maniaci Interview, Pasadena Police Department, Memorable Characters Created By Arthur Miller, Articles D